Work

Valorization of Pomegranate Peel: Mechanisms and Clinical Applications in Irritable Bowel Syndrome Management

Year: 2025

Type: article

Abstract: Current disposal methods for pomegranate peel (PP) waste are inadequate, resulting in environmental pollution. Given PP's therapeutic potential in alleviating irritable bowel syndrome (IBS), elucidating its bioactive mechanisms is critical to guide its development into dietary supplements and promote sustainable recycling. In this study, bioinformatics and network analysis were employed to identify active compounds, key targets, and signaling pathways associated with PP's therapeutic effects. We identified 39 bioactive compounds (primarily polyphenols) and 106 key targets linked to IBS. Network analyses revealed that PP polyphenols mitigate oxidative stress and inflammation, modulate estrogen receptors to enhance gastrointestinal motility, and regulate ferroptosis. These findings underscore PP's potential as a therapeutic agent for IBS and provide a framework for repurposing food-processing byproducts.

Source: International Journal of Molecular Sciences

DOI: 10.3390/ijms26083530

Authors: Yu Guo, Lu Wang, Jun-Qing Huang, Mu-Wen Lu, Song-Hong Yang

Institutions: Jiangxi University of Traditional Chinese Medicine, Jinan University, Universidade de Vigo, South China Agricultural University

Language: English

Topic: Pomegranate: compositions and health benefits

Subfield: Nutrition and Dietetics

Field: Nursing

Domain: Health Sciences

SDGs: Responsible consumption and production, Good health and well-being

Open Access status: gold

Estimated APC paid: $3,499