Work

Isolation, Identification, Biochemical profile and antifungal effect against Candida spp. of an actinomycete isolated from Aniba parviflora rhizosphere on Amazon region, Brazil

Year: 2025

Type: article

Abstract: This work evaluated the antifungal potential of Streptomyces sp. MPO-3 isolated from rhizospheric soil of Aniba parviflora Syn fragans (Macacaporanga). Bioactive compounds were retrieved from submerged fermentation broth by ethyl acetate extraction. The extraction resulted in ethyl acetate crude extract, and this preparation was taken to be evaluated against Candida albicans and Candida krusei. The ethyl acetate showed being active against tested Candida spp. The time course profile assay showed that 24 h of fermentation returned bioactive molecules with inhibition power against C. albicans and 72 h for C. krusei. The minimum fungistatic concentration assay reached 78.1µg/mL for C. albicans and 156 µg/mL for C. krusei. Based on the results presented here, the strain Streptomyces sp. MPO-3 showed the ability to produce active metabolites with an anti-candida effect.

Source: OBSERVATÓRIO DE LA ECONOMÍA LATINOAMERICANA

DOI: 10.55905/oelv23n4-059

Authors: Apolonio Alves de Lima Junior, Ednan Cardoso de Sousa, Thales Henrique Barbosa de Oliveira, Raphael Carlos Férrer de Santana, Silvia Katrine Rabelo da Silva, Luana Cassandra Breitenbach Barroso Coelho

Institutions: Universidade Federal de Pernambuco, Universidade de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Centro Universitário Maurício de Nassau, Universidade Federal do Oeste do Pará

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: diamond

OpenAlex ID: W4409287000

FWCI: 0.494

Cites: 4

Cited by: 1

Related to: 10