Year: 2025
Type: article
Abstract: Circular RNAs (circRNAs), once thought to be a result of splicing errors, have been found to be involved in various molecular processes and the pathology of various diseases, including cancer and neurodegenerative diseases. Additionally, circRNA expression was found to be altered by lifestyle habits, such as smoking cigarettes. Past studies have revealed that the rate of smoking remains high in people living with human immunodeficiency virus (HIV). In this study, we isolated total RNA from uninfected T-cells that have been exposed to cigarette smoke and compared the expression levels of circRNAs to those of T-cells that were not exposed to cigarette smoke. We identified certain circRNAs that were upregulated or downregulated in T-cells when exposed to cigarette smoke. These data indicate that the study of circRNAs is warranted within the context of HIV.
Source: F1000Research
Institutions: Johns Hopkins University, Pennsylvania State University
Language: English
Topic: Circular RNAs in diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,350
Awards: Extracellular Vesicle-Mediated Immunomodulation in HIV Infection and Nicotine Abuse, G6079011624, Novel Separation Methods for exRNA Carriers: Extracellular Vesicles, Lipoprotein Particles, and Protein Aggregates, G8773427133, Extracellular Vesicle and Extracellular RNA Biomarkers of HIV-1 Central Nervous System Pathogenesis and Cigarette Use
OpenAlex ID: W4409291872