Work

Access to Fully Substituted Furans via Boryl Radical Catalyzed Cycloisomerization of Cyclopropenyl Ketones

Year: 2025

Type: article

Abstract: We report the boryl radical catalyzed cycloisomerization of cyclopropenyl ketones to fully‐substituted furans, a type of highly important pharmacophore and synthetic intermediate. The reaction features neutral conditions, high yields, and toleration of variation at all possible positions of the substrate, making it an indispensable route for this type of important scaffold. Preliminary downstream transformation also revealed the synthetic potential of these furans in accessing other types of furans or more complex 3D scaffolds.

Source: Asian Journal of Organic Chemistry

DOI: 10.1002/ajoc.202500126

Authors: Xingran Yang, Jiahang Li, Jinbo Zhao

Institution: Changchun University of Technology

Language: English

Topic: Cyclopropane Reaction Mechanisms

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: Natural Science Foundation of Jilin Province, Changchun University of Technology, National Natural Science Foundation of China, People's Government of Jilin Province

Awards: G2161596020, G300466502, G7579060178