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Cancer vulnerabilities exposed by finding interactions among DNA repair factors

Year: 2025

Type: article

Abstract: A screen of interactions between genes involved in the cell’s response to DNA damage has revealed several previously unreported ‘synthetic lethalities’, in which disrupting a pair of genes, but not either gene alone, causes cell death. The resulting map of genetic interactions could help to identify therapeutic targets for cancer. A screen of almost 150,000 pairwise combinations of genes could help to identify targets for cancer treatment.

Source: Nature

DOI: 10.1038/d41586-025-01049-4

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $12,690

OpenAlex ID: W4409292974

FWCI:

Cites: 5

Cited by:

Related to: 10