Hemato- Biochemical Profile of Malaria Patients in Sub Saharan Africa: A Case of the Urban Health Center of Franceville, Gabon
Year: 2025
Type: article
Study design: Observational Study
Abstract: Hemato-biochemical analysis is essential for optimal management, reducing the mortality and sequelae of malaria, particularly in endemic areas such as Gabon. This cross-sectional study examined hematological and biochemical changes associated with malaria in 154 patients at the Franceville Urban Health Center (July-September 2024). A high malaria prevalence of 66.88% (95% CI: 0.6-0.74), a severe reduction in erythrocytes (OR=16.59, 95% CI[6.82-43.94], p<0.001), elevated leukocytes (OR=5.6, 95% CI[2.57-2.7], p<0.001), marked thrombocytopenia (OR=15.59, 95% CI[5.86-49.3], p<0. 001), a significant increase in ALT (OR=6.67, 95% CI [3.85-20.47], p<0.001), an increase in AST in 42.21% of patients (OR=0.37, 95% CI [0.14-0.88], p<0.001), and finally, an increase in CRP levels (OR=0.6, 95% CI [0.28-1.26], p<0.001), were found as results. This study demonstrates the profound effects of malaria on the hematopoietic and hepatic systems, underlining the need for comprehensive monitoring of these parameters in clinical management.
Institution: Université des Sciences et Techniques de Masuku
Language: English
Topic: Malaria Research and Control
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4409295378