Work

Development of Biginelli-based ZnO-coupled carbomer-gel-coated wound dressing gauze with enhanced antibacterial activity

Year: 2025

Type: article

Abstract: A multicomponent Biginelli reaction was used to produce biologically active dihydropyrimidones that were then combined with ZnO nanoparticles. Biginelli compounds synthesized with various alkyl chains were characterized using high-resolution mass spectrometry as well as 1H- and 13C-NMR spectroscopy. Efficient antibacterial gels were developed by introducing the prepared Biginelli compounds and ZnO nanoparticles into a carbomer polymer matrix. Antibacterial screening revealed that the ABS-G4 gel exhibited the highest antibacterial potential, with minimum inhibitory concentrations of 16 ± 2 and 12 ± 2 µg/mL against Escherichia coli and Staphylococcus aureus, respectively. The ABS-G4 gel was characterized using rheological studies, field-emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, powder X-ray diffraction, and atomic force microscopy. The ABS-G4 gel was showing more antibacterial efficacy toward Gram-positive strains of bacteria than Gram-positive ones. An antibacterial dressing was formed by coating the developed gel onto a gauze dressing.

Source: RSC Advances

DOI: 10.1039/d5ra00236b

Authors: Bulle Shah, Narinder Singh, Doo Ok Jang

Institutions: Indian Institute of Technology Ropar, Yonsei University, Yonsei University Mirae Campus

Language: English

Topic: Wound Healing and Treatments

Subfield: Rehabilitation

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,042