Work

Breath of change: Evaluating the healthcare impact of the race-neutral Global Lung Initiative (GLI) 2022 on adults with cystic fibrosis

Year: 2025

Type: article

Abstract: This study evaluates the clinical impact of transitioning from the GLI 2012 to the race-neutral GLI 2022 spirometry equations in people with cystic fibrosis (pwCF). Spirometry data from a large adult CF centre showed an increase in average ppFEV 1 (71.1 %–75 %, p < 0.01), with White patients showing the greatest change (4.56 %). Fewer patients met lung transplantation thresholds, and 1.7 % became newly eligible for clinical trials, while 7 % became ineligible. These findings suggest the need for further research on the long-term implications of GLI 2022 across respiratory conditions.

Source: Respiratory Medicine

DOI: 10.1016/j.rmed.2025.108086

Authors: Aqeem Azam, Peter James Barry, Rowland Bright-Thomas, Alex Horsley, Andrew Jones

Institutions: University of Manchester, Manchester University NHS Foundation Trust

Language: English

Topic: Cystic Fibrosis Research Advances

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,630