Work

Targeting USP11 counteracts SFTPCI73T-associated interstitial lung disease in hiPSCs-derived alveolar organoids and in vivo models

Year: 2025

Type: article

Abstract: Altogether, USP11 is a major protein stabilizer of SFTPC, and the clinical inhibition of USP11 during PF could be a novel therapeutic approach for ILD patients.

Source: Theranostics

DOI: 10.7150/thno.105994

Authors: Janardhan Keshav Karapurkar, Sripriya Rajkumar, Ji-Hye Jung, Ji-Young Kim, Girish Birappa, D. A. Ayush Gowda, Jencia Carminha Colaco, Bharathi Suresh, Jung-Yun Choi, Sang Hyeon Woo, Won-Jun Jo, Jong-Hee Lee, Kye-Seong Kim, Seok-Ho Hong, Suresh Ramakrishna

Institutions: Hanyang University, Kangwon National University, Korea Research Institute of Bioscience and Biotechnology

Language: English

Topic: Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,671

OpenAlex ID: W4409300629

FWCI: 3.038

Cites: 1

Cited by: 5

Related to: 10