Work

Exploring Fungi Within the Human Gut Microbiota: Obstacles, Innovations, Therapeutic Applications and Prospects Ahead

Year: 2025

Type: article

Abstract: Fungi in the human gut microbiota participate in the maintenance of health and regulation of physiological processes. This review examines the complex role of gut fungi, highlighting challenges such as diverse fungal populations, cultivation difficulties, and knowledge gaps in their functional roles. Recent advancements in metagenomics and metabolomics have enabled innovative investigations into fungal communities, revealing their influence on host metabolism and immune responses. Future research should address the existing knowledge gaps and explore the therapeutic applications of gut fungi. Interdisciplinary collaborations and new methodologies are proposed to enhance the current understanding of fungi-host interactions, ultimately improving health outcomes and guide the development of novel treatment strategies. This review emphasizes the need to integrate fungal research into microbiome studies to provide a comprehensive understanding of gut health.

Source: International Journal of Drug Discovery and Pharmacology

DOI: 10.53941/ijddp.2025.100007

Authors: Peng Xue, Chao Luo, Jiashu Li, Liang Yang, Yuanyuan Ma

Institutions: Nantong University, Affiliated Hospital of Nantong University, Southern University of Science and Technology

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Natural Science Foundation of Jiangsu Province