Year: 2025
Type: article
Abstract: Tight regulation of messenger RNA (mRNA) stability is essential to ensure accurate gene expression in response to developmental and environmental cues. mRNA stability is controlled by mRNA decay pathways, which have traditionally been proposed to occur independently of translation. However, the recent discovery of a co-translational mRNA decay pathway (also known as CTRD) reveals that mRNA translation and decay can be coupled. While being translated, a mRNA can be targeted for degradation. This pathway was first described in yeast and rapidly identified in several plant species. This review explores recent advances in our understanding of CTRD in plants, emphasizing its regulation and its importance for development and stress response. The different metrics used to assess CTRD activity are also presented. Furthermore, this review outlines future directions to explore the importance of mRNA decay in maintaining mRNA homeostasis in plants.
Source: Journal of Experimental Botany
DOI: 10.1093/jxb/eraf146
Authors: Jean-Marc Deragon, Rémy Merret
Language: English
Topic: RNA Research and Splicing
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: Towards a Unified theory of biotic Interactions: the roLe of environmental, tRNA epitranscriptome dynamics: molecular and phenotypic consequences on plant development and stress responses, G3264115735, G39567056, G3960473525, Molecular Analysis and physiological importance of 5’-3’ co-TranslatIonal mRNA Decay in Arabidopsis, G4656594441, G7240651115, G7658697405, The Toulouse-Perpignan
OpenAlex ID: W4409301201