Thành Phần Hóa Học Và Hoạt Tính Kháng Vi Sinh Vật Của Tinh Dầu Thân Giả Loài Conamomum Vietnamense
Year: 2025
Type: article
Abstract: Conamomum vietnamense, a newly identified species of the Zingiberaceae family, was discovered in Lam Dong, Vietnam, in 2022. This study examined the chemical composition and antimicrobial activity of the essential oil extracted from its pseudo-stems. The essential oil was obtained via hydrodistillation and analyzed using gas chromatography-mass spectrometry (GC/MS). Monoterpene hydrocarbons (59.55%) were identified as the predominant class of compounds in this essential oil, with α-limonene (32.73%) and 1,8-cineole (12.71%) as two main components. Additionally, the essential oil demonstrated antimicrobial activity, with inhibitory efficacy as follows: E. faecalis ≈ C. albicans (MIC = 32 µg/mL) > B. cereus ≈ S. enterica (MIC = 64 µg/mL) > S. aureus ≈ P. aeruginosa (MIC = 128 µg/mL) > E. coli (MIC = 256 µg/mL). A molecular docking study was conducted to investigate ligand-protein interactions involving the major constituents of the essential oil and key proteins from E. faecalis, S. aureus, B. cereus, E. coli, and C. albicans. The present study revealed that 1,8-cineole and α-pinene exhibited strong binding affinities to E. coli, whereas (6E)-nerolidol demonstrated a higher interaction with the 1IYL protein against C. albicans. Furthermore, α-limonene and α-phellandrene exhibited notable antimicrobial activities against both C. albicans and E. coli. This is the first report on the chemical composition of C. vietnamense pseudo-stem essential oil and its antimicrobial activity.
Source: Tạp chí Dược liệu
Authors: Ngô Thị Thúy, Trần Trung Hiếu, Ngũ Thị Hà Giang, Nguyễn Thị Thu, Nguyễn Hoàng Tuấn, Nguyễn Văn Thư
Language: English
Subfield: Food Science
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4409303445