Synthesis of Iron Porphyrin with Pendant Thiol Groups: Progress Toward a Model of the Heme/Cu Active Site of Sulfite Reductase
Year: 2025
Type: article
Abstract: The heme/Cu sulfite reductase bears a distal Cu metal coordinated to two cysteines. This enzyme catalyzes the reduction of sulfite to H 2 S. Very little is known about the electronic structure and reactivity of this enzyme. Synthetic modelling can allow access to the properties of the active site. However, installing thiolates on porphyrin rings is not adequately represented in the literature. In this paper, we describe a synthetic methodology to install multiple thiolates on porphyrin rings which can be used to bind a second metal. In addition, to the complexity of keeping several thiols adjacent to each other, this work also reports unprecedented demetallation of iron porphyrin in the presence of multiple thiol functional groups in the vicinity.
Source: Chemistry - An Asian Journal
Authors: Souvik Dinda, Ankita Sarkar, Kumarjit Banerjee, Rajat Saha, Triparna Roy, Abhishek Dey
Institution: Indian Association for the Cultivation of Science
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: bronze
Award: G4183943030
OpenAlex ID: W4409305837