The diagnostic value of angiotensin, g-GT, blood lactate, and renal resistance index combined detection in acute kidney injury after neonatal asphyxia
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: To investigate the diagnostic value of angiotensin (Ang), gamma-glutamyltransferase (g-GT), blood lactic acid and renal resistive index (RRI) for acute kidney injury (AKI) after neonatal asphyxia. Methods: A total of 120 asphyxiated neonates admitted to the hospital from May 2021 to April 2024 were retrospectively selected. According to whether AKI occurred after asphyxia, the neonates were divided into AKI group and non-AKI group. The occurrence of AKI in neonates with different degrees of asphyxia was analyzed. Plasma Ang-I and Ang-II levels and urine g-GT level were compared between the AKI group and the non-AKI group. The blood gas analyzer was used to determine blood lactic acid levels and color Doppler ultrasound was used to evaluate RRI. The correlation between blood Ang, urine g-GT, blood lactic acid, RRI and serum creatinine (Scr) and blood urea nitrogen (BUN) was discussed. Multivariate logistic regression model was used to identify factors influencing the occurrence of AKI after neonatal asphyxia. The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficacy of relevant indicators for AKI after neonatal asphyxia.
Source: Journal of Medical Biochemistry
DOI: 10.5937/jomb0-56995
Authors: Xiaoqing Shi, Liying Dai, Ying Wang, Fang Deng
Language: English
Topic: Acute Kidney Injury Research
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4409305923