Year: 2025
Type: article
Study design: Case Report
Abstract: Background: Perivascular spaces (PVS) are fluid-filled cavities located in the brain that surround blood vessels. Dilated PVS (dPVS) can be discerned on MRI in healthy individuals. Extreme expansion of PVS is classified as giant tumefactive PVS (GTPVS), a rare condition with an ambiguous etiology. Although GTPVS may exert a mass effect, it should not be misidentified as a tumor or other pathological conditions. Case presentation: We report a rare case of GTPVS that was incidentally discovered during the examination of a scalp mass. The patient exhibited giant tumefactive dilation of PVS in the left cerebral hemisphere without any clinical symptoms. The MR imaging of this case showed a typical cluster cyst. Based on the location of the lesion, consider it belongs to Type II GTPVS. Conclusion: This study reports a rare GTPVS case, establishing diagnostic criteria, differential diagnosis, and management strategies. While asymptomatic cases require no treatment, hydrocephalus may necessitate surgery. Literature review suggests PVS dilation reflects glymphatic dysfunction, providing new pathophysiological insights. Further studies are needed to validate these findings due to the condition's rarity.
Source: Frontiers in Neuroscience
Authors: Chang Cheng, Yiqi Pan, Ke Ma, Shuhan Liu, Xiaoli Mai
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4409308369