Work

Synthesis of Fused-Housane Derivatives via Intramolecular [2 + 2] Photocycloaddition

Year: 2025

Type: article

Abstract: Herein, we describe a [2 + 2] photocycloaddition of cyclopropenes bearing a styryl group to prepare housane derivatives. The reaction occurs via selective excitation of the styrene fragment, enabling a completely stereoselective stepwise [2 + 2] cycloaddition. Fused-housane derivatives with an unprecedented substitution pattern are prepared in a simple manner using convenient visible light.

Source: Organic Letters

DOI: 10.1021/acs.orglett.5c00468

Authors: David Suárez-García, Miguel A. Rodríguez, Iratxe Barbolla, Rubén Vicente

Institutions: Universidad de Oviedo, ORFEO-CINQA Research Network, Universidad de La Rioja

Language: English

Topic: Cyclopropane Reaction Mechanisms

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: Gobierno del Principado de Asturias, Ministerio de Ciencia, Innovación y Universidades, Agencia Estatal de Investigación