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Altered Expression of Interleukin-6, Glycodelin A and Heparin-Binding Epidermal Growth Factor, in The Endometrium of Women with Hydrosalpinx: A Case-Control Study.

Year: 2025

Type: article

Abstract: BACKGROUND: in the endometrium of women exposed to hydrosalpinx fluid (HF) compared to the fertile group. MATERIALS AND METHODS: In this case-control study, 30 subjects were enrolled for this study: fifteen patients with communicating hydrosalpinx (aged between 20-37 years old) were compared with 15 fertile aged-matched egg donor women as the control group. All subjects underwent uterine endometrial sampling by Pipple on days 19-24 of the menstrual cycle. Gene expression was quantitatively analyzed using a real-time polymerase chain reaction (PCR) technique. Data analysis was conducted using the Wilcoxon rank test. RESULTS: gene expression was significantly reduced in the hydrosalpinx group compared to fertile women (P=0.007). There was an insignificant decrease in GdA mRNA expression level compared to healthy fertile controls (P=0.419). CONCLUSION: mRNA levels in the implantation window, which may explain the reduced implantation rate and success in IVF outcome.

Source: PubMed

DOI: 10.22074/ijfs.2024.1996107.1447