Therapeutic Effects of Cynodon dactylon (C. dactylon) against Polycystic Ovary Syndrome Induced by Letrozole in Adult Rats: Ovarian and Uterine Aspects.
Year: 2025
Type: article
Abstract: BACKGROUND: hydroalcoholic extract of on letrozole-induced polycystic ovary syndrome (PCOS) in adult rats. MATERIALS AND METHODS: extract on receptors involved in the pathophysiology of PCOS. RESULTS: extract mitigates PCOS-induced hormonal imbalances including a significant decrease in testosterone and estrogen levels, as well as increased progesterone levels. Ovarian and uterine structures were improved including reducing theca layer thickness, enhancing antral follicular areas, and a significant decrease in the luminal area of the perimetrial layer, endometrial glands, and the total uterine area when compared to the PCOS group. Besides, molecular docking analysis showed that Ar-tumerone, Tumerone, Tricyclo[6.3.0.0(1,5)] undec-2-en-4-one, 2,3,5,9- tetramethyl, Curlone, and 3-Tert-butyl-4-hydroxyanisole showed the most binding affinity to the receptors that play crucial role in the pathophysiology of PCOS. CONCLUSION: had therapeutic effects on the ovary and uterus of PCOS-induced rat models.
Source: PubMed
Authors: Masoumeh Ahmadi, Afshin Zare, Mohammad Reza Jafarzadeh Shirazi, Samaneh Askari, Arezoo Khoradmehr, Nadiar M Mussin, Asset A Kaliyev, Farzad Mohammad Rezazadeh, Saman Saedi, Mohammad Dadpasand Taromsari, Alidad Boostani, Nader Tanideh, Kulyash R Zhilisbayeva, Ramazon Safarzoda Sharofiddin, Amin Tamadon
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: Shiraz University
OpenAlex ID: W4409315201