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Nuclear Receptors in Platelet Activation and Thrombosis in Hypercholesterolemia

Year: 2025
Type: editorial
Abstract: In 1957, the Framingham Heart Study introduced the term "cardiovascular risk factor" after identifying various factors that influence heart disease.High blood pressure, high cholesterol, smoking, obesity, diabetes, and physical inactivity have since been recognized as key risk factors for stroke, pulmonary embolism, coronary artery disease, and heart failure 1 .Despite these insights, cardiovascular disease remains the leading cause of death in the United States.Interestingly, multiple studies have reported increased platelet reactivity in hypercholesterolemia without offering a mechanistic explanation for this phenomenon 2-4 .In the current issue of Circulation Research, Liu et al. describe a non-canonical function of the
Language: English
Subfield: Hematology
Field: Medicine
Open Access status: green
OpenAlex ID: W4409317396
Cites: 14
Cited by:
Related to: 10