Work

The toxicity, uptake, and impact on galectin-3 mediated apoptosis of lactose functionalized PAMAM dendrimers

Year: 2025

Type: article

Abstract: Four generations of lactose-functionalized PAMAM dendrimers show low toxicity, proclivity for uptake, and mediation of galectin-3 inhibition of apoptosis. Glycodendrimers are useful systems for studying galectin-3 in cancer cells.

Source: Materials Advances

DOI: 10.1039/d4ma00782d

Authors: Mackenzie S. Fricke, Magalee R. Frometa, Yannic Kerkhoff, Samuel P. Bernhard, Ramat S. Tahir, Elisa Quaas, William H. Totten, Rainer Haag, Katharina Achazi, Mary J. Cloninger

Institutions: Montana State University, Zuse Institute Berlin, Freie Universität Berlin

Language: English

Topic: Dendrimers and Hyperbranched Polymers

Subfield: Polymers and Plastics

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,962

Funders: National Science Foundation, U.S. Department of Defense, M.J. Murdock Charitable Trust, Montana State University, Deutsche Forschungsgemeinschaft, Defense Human Resources Activity, Division of Electrical, Communications and Cyber Systems, Division of Chemistry

Awards: NNCI: Montana Nanotechnology Facility (MONT), G2928889116, G3112545571, G3256030172, G3821860108, G4257198055, MRI: Acquisition of a Multi-Modality Multi-Photon Digital Light Sheet Microscope in the Pacific Northwest to Support Bioengineering Research and Development, G7558645075, Using Glycodendrimers to Elucidate the Importance of Multivalency in the Structures and Functions of Galectins

OpenAlex ID: W4409326929

FWCI: 0.231

Cites: 74

Cited by: 1

Related to: 10