Year: 2025
Type: article
Study design: Observational Study
Abstract: Background and Aim: Uveitis is a group of inflammatory eye disorders with various etiologies, including genetic susceptibility. Certain Human Leukocyte Antigen (HLA) types are known to be associated with different forms of uveitis. This study aims to identify disease-susceptible HLA types (DSHTs) for each type of uveitis. Methods: 120 patients with uveitis (47 patients with anterior uveitis, 33 patients with posterior uveitis and 32 patients with panuveitis) were enrolled in the study. After determining the relative risk values according to the types of uveitis, we have revealed HLA types with relative risk values bigger than 1(DSHTs) for each type of uveitis. Results: 1) For patients with anterior uveitis, DSHTs were HLA-B27, HLA-A26, HLA-DR10. 2) For patients with posterior uveitis, DSHTs were HLA-A29, HLA-B44 and HLA-DR4. 3) For patients with panuveitis, DSHTs were HLA-DR4, HLA-B51, HLA-A26 and HLA-DR11. Conclusion: These findings highlight genetic predispositions that may aid in early diagnosis and targeted management.
Authors: Hyangsun Kim, Ilhyok Kang, Yongae An, Mihyang Hong, Chunghyok Ri, Chol Sin
Institution: Pyongyang Medical University
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4409338677