Work

Antibiotic use and financial impact of a comprehensive beta-lactam allergy management program

Year: 2025

Type: article

Abstract: Objective: A multidisciplinary beta-lactam allergy management program was implemented at our community medical center to facilitate allergy documentation, conduct penicillin skin testing (PST), and decrease non-beta-lactam (NBL) use. This study measures PST-associated antibiotic use and financial outcomes. Design: Cohort study. Setting: Non-teaching, urban, community medical center within a multi-hospital health system. Patients: Adult inpatients who underwent PST and received antibiotic therapy during a 5-year period at our facility. Methods: Demographics, allergies, laboratory results, PST outcome, and antimicrobial regimens were assessed. Actual NBL days of therapy (DOT) were collected from the electronic medical record. NBL DOT that patients would have received without PST were modeled by forecasting the original regimen to end of inpatient treatment. Difference between actual and forecasted DOT was deemed DOT avoided (DOT-A) for each consecutively enrolled patient. The financial analysis evaluated cumulative NBL cost avoided. PST outcomes and average time from antibiotic initiation to PST were assessed. Results: The study included 600 patients who underwent PST an average of 3.7 days into treatment. The most common indication was acute bacterial skin and skin structure infections (23.9%). PST results were negative in 98% of patients. NBL DOT-A was 944.8/1000DT (8.8 DOT-A per intervention) accounting for an estimated cost savings of $206,500 ($344.10 per intervention), driven primarily by aztreonam avoidance. Conclusions: This study highlights significant avoidance of NBL DOT in one of the largest identified cohort of inpatients undergoing PST. Associated cost avoidance contributes to the sustainability and longevity of the allergy management program.

Source: Antimicrobial Stewardship & Healthcare Epidemiology

DOI: 10.1017/ash.2025.36

Authors: Karan Raja, Lakhini Vyas, Susan Morrison, Donald Beggs, Mitesh Patel, Mona Philips

Institution: Rutgers, The State University of New Jersey

Language: English

Topic: Antibiotic Use and Resistance

Subfield: Applied Microbiology and Biotechnology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,719