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The challenge of determining the health risks of low-dose chemical exposures

Year: 2025

Type: article

Abstract: The challenge of determining the health risks of low-dose chemical exposures Rebecca J. Wilson and Pamela J. Lein, explore whether the dose makes the poison or not. Here, they discuss the challenges of determining health risks associated with low-dose chemical exposures. Nearly 500 years ago, Swiss physician and chemist Paracelsus originally expressed a fundamental tenet of toxicology: “All things are poison and nothing is without poison; only the dose makes a thing not a poison.” In other words, all substances are harmful at a high enough dose, but at low doses, the same substance is non-toxic or even therapeutic.

Source: Open Access Government

DOI: 10.56367/oag-046-10177

Authors: Rebecca J Wilson, Pamela J Lein

Institution: University of California, Davis

Language: English

Topic: Carcinogens and Genotoxicity Assessment

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4409340844