Work

High-glucose-associated YTHDC1 lactylation reduces the sensitivity of bladder cancer to enfortumab vedotin therapy

Year: 2025

Type: article

Abstract: A-dependent manner, subsequently decreasing NECTIN4 expression and EV responsiveness. Our study identifies a high-glucose-associated lactate-AARS1-YTHDC1-JUND-NECTIN4 axis that affects EV sensitivity in BC. Targeting this axis with JUND activators or β-alanine may offer therapeutic strategies to enhance the sensitivity of BC cells to EV.

Source: Cell Reports

DOI: 10.1016/j.celrep.2025.115545

Authors: Zhuo Xing, Tiejun Yang, Xurui Li, Haozhe Xu, Yulong Hong, Shuai Shao, Tao Li, Liefu Ye, Yuan Li, Xin Jin, Yongbao Wei

Institutions: Central South University, Second Xiangya Hospital of Central South University, Zhengzhou University, Henan Cancer Hospital, Fujian Medical University, Fujian Provincial Hospital, Fuzhou University

Language: English

Topic: RNA modifications and cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,620

Funders: Health Commission of Henan Province, National Natural Science Foundation of China, Central South University, Natural Science Foundation of Fujian Province, Excellent Youth Foundation of Jiangsu Scientific Committee, National Key Clinical Specialty Discipline Construction Program of China

Awards: G2189510684, G5335002884, G5469038298, G7023751985, G8024799908, G8110840037, G826607973, G8452922157

OpenAlex ID: W4409341754

FWCI: 8.057

Cites: 84

Cited by: 32

Related to: 10