Work

High-grade corded and hyalinized endometrioid carcinoma of “no specific molecular profile”: report of two cases

Year: 2025

Type: article

Abstract: mutations. The corded component was absent in the hysterectomy specimen of case #1 and in the vaginal biopsy specimen of case #2. The present cases confirm the clinical and molecular heterogeneity of high-grade CHEC, including a wide age range at presentation, variable prognosis, and variable molecular background. Nonetheless, these cases retain unique features that support their distinction from carcinosarcoma and dedifferentiated carcinoma. We suggest to consider them as a variant of FIGO G3 endometrioid carcinoma. Further studies are necessary in this field.

Source: Pathologica

DOI: 10.32074/1591-951x-1096

Authors: Antonio Travaglino, Damiano Arciuolo, Angela Santoro, Susanna Ronchi, Nicoletta D’Alessandris, Giulia Scaglione, Belen Padial Urtueta, Francesca Addante, Nadine Narducci, Michele Valente, Antonio Raffone, Jvan Casarin, Carla Facco, Stefano La Rosa, Gian Franco Zannoni

Institutions: University of Insubria, Aziende Socio Sanitarie Territoriale dei Sette Laghi, Università Cattolica del Sacro Cuore, Agostino Gemelli University Polyclinic, University of Bologna

Language: English

Topic: Endometrial and Cervical Cancer Treatments

Subfield: Obstetrics and Gynecology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4409342298

FWCI: 1.07

Cites: 13

Cited by: 1

Related to: 10