Work

Enhanced antimicrobial efficacy by impregnation of vascular grafts with nanocolloidal silver

Year: 2025

Type: article

Abstract: Objective: This in vitro study aims to evaluate any additional antimicrobial efficacy by impregnating nanocolloidal silver on commercially available vascular grafts, to compare the results with precoated silver grafts, and to test the feasibility of the procedure. Methods: In addition, the untreated grafts from polyester and bovine pericardium, as well as the precoated silver grafts, were cut and incubated analogously, resulting in 5 groups of 80 GUs each (n = 400). After incubation, each GU was washed and sonicated and samples from each sonication fluid were plated on separate Müller-Hinton Agar (MH) plates. These were incubated at 37°C and CFU were counted after 24 hours. Results: = .721). In addition, no significant difference between the impregnated grafts and the precoated silver graft was demonstrated after 24 hours of incubation. Conclusions: Impregnating vascular grafts from polyester and bovine pericardium with a nanocolloidal silver spray, before inoculation with a bacterial suspension, significantly reduced bacterial colonization on the grafts. The procedure proved feasible and should be tested further in in vitro and in vivo trials.

Source: JVS Vascular Science

DOI: 10.1016/j.jvssci.2025.100286

Authors: Karin Lindén, Philipp Seeger, Samira Weisselberg, Eike Sebastian Debus

Institution: University Medical Center Hamburg-Eppendorf

Language: English

Topic: Infectious Aortic and Vascular Conditions

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,800