Work

Exploring Clinical and Imaging Differences in COVID-19: an Observational Approach to the IFITM3 rs12252 Polymorphism

Year: 2025

Type: article

Abstract: Purpose: The severity of COVID-19 infections varies among individuals, prompting research into factors that may influence outcomes. Numerous studies have investigated the conditions that influence the intensity of illness caused by COVID-19. These factors include the Interferon-Induced Transmembrane Protein 3 (IFITM3) rs12252 polymorphism. We investigate whether the polymorphism rs12252 plays a role within our population and observe the differences in other parameters between the mild and severe forms of the disease. Patients and Methods: The observational study examining the IFTIM3 rs12252 polymorphism based on the level of COVID-19 severity and differences between inflammatory markers. The study included 51 participants, with 31 severe and 20 mild cases. Results: The average age of participants was 54 years, and 16.1% of patients with severe symptoms were diagnosed with the AG genotype. Patients showing serious symptoms had significantly higher ESR, CRP, Fibrinogen, LDH, and D-dimer levels than those with mild symptoms. Conclusion: This study discovered a notable correlation between the G allele of IFITM3 rs12252, inflammatory markers, CT scan score, and COVID-19 severity.

Source: International Journal of General Medicine

DOI: 10.2147/ijgm.s512160

Authors: Adriana Mitrea, Anca-Florentina Mitroi, Cristian Opariuc-Dan, Ancuta-Alina Constantin, Elena Dantes

Institutions: Ovidius University, Carol Davila University of Medicine and Pharmacy, Institutul de Pneumoftiziologie "Marius Nasta"

Language: English

Topic: COVID-19 Clinical Research Studies

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,836