Work

Psychoeducational Program Increases Telomerase Activity in Bipolar Disorder: A Gender‐Based Randomized Controlled Trial

Year: 2025

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: ABSTRACT Aims This randomized controlled trial evaluated the efficacy of a psychoeducational program in enhancing telomerase activity (TA) among patients with bipolar disorder (BD), with a specific focus on gender differences. Methods A total of 62 participants were assigned to either the psychoeducation (PE) group or the control (CTR) group, with TA measured both before and after the intervention. Results Results demonstrated a significant increase in TA in the PE group compared to the controls at the conclusion of the study. Notably, gender‐specific analyses revealed that female participants showed significant increases in both TA and delta TA (Δ TA ), with Δ TA PE = 0.586 ± 0.273 and Δ TA CTR = −0.251 ± 0.177. In contrast, male participants exhibited significant changes only in Δ TA , with Δ TA PE = 0.257 ± 0.138 and Δ TA CTR = −0.144 ± 0.1194. Conclusion These findings suggest that psychoeducational interventions have differential gender‐specific effects, underscoring the importance of personalized approaches in the treatment of BD.

Source: CNS Neuroscience & Therapeutics

DOI: 10.1111/cns.70292