Work

Palladium-catalysed regio- and stereo-controlled C-2 β-fluorovinylation of indoles

Year: 2025

Type: article

Abstract: -Fluorovinyl iodonium salts, which are formed from alkynes through a Ag-catalysed process, engage in a palladium-catalysed C-2 C-H functionalisation of indoles (and pyrroles) to achieve a broad scope of β-fluorovinyl heterocycles in good to excellent yields. Mechanistic studies and product derivatisations are provided.

Source: Organic Chemistry Frontiers

DOI: 10.1039/d5qo00521c

Authors: Atul K. Chaturvedi, Alastair J. J. Lennox

Institution: University of Bristol

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Funders: Royal Society, European Research Council, H2020 European Research Council

Awards: Selective Electrochemical Nucleophilic Fluorination, G5112312405