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Therapeutic Potential of Plant‐Derived Peptides for Preventing or Treating Hypertension and Diabetes

Year: 2025

Type: article

Abstract: ABSTRACT Interest in plant‐derived bioactive peptides (BAPs) is increasing due to their potential therapeutic effects, low toxicity, abundance, scalability, and cost‐effectiveness. These peptides can be obtained by hydrolyzing plant proteins from a diverse range of sources, including legumes, cereals, grains, oilseeds, and tubers. This review discusses the benefits of these peptides on human health, addressing current challenges in translating research into practical use. The structural aspects of peptides combating hypertension and diabetes, encompassing structure–activity relationship studies, in vitro and in vivo methodologies, and absorption pathways are also discussed. Additionally, it explores the molecular features, physicochemical properties, gastrointestinal fate, and biological activities of various plant‐derived peptides, including their potential in reducing blood pressure and blood sugar. These peptides hold promise as therapeutic agents in functional foods, supplements, and pharmaceuticals, pending rigorous human clinical trials to ascertain efficacy and safety. Successful trials could position plant‐derived peptides as innovative antihypertensive and antidiabetic agents.

Source: Journal of Food Process Engineering

DOI: 10.1111/jfpe.70087

Authors: Debojit Baidya Choudhury, Tariq Abdullah Mir, Khalid Gul, Rachna Sehrawat, David Julian McClements

Institutions: National Institute of Technology Rourkela, Sher-i-Kashmir Institute of Medical Sciences, University of Massachusetts Amherst

Language: English

Topic: Protein Hydrolysis and Bioactive Peptides

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4409362202

FWCI: 1.015

Cites: 165

Cited by: 4

Related to: 10