Optimizing Metastatic Risk Prediction in High-Risk Cutaneous Squamous Cell Carcinoma with Gene Expression Profiling
Year: 2025
Type: article
Study design: Observational Study
Abstract: This Blue-Ribbon poster presentation, ranking among the top five abstracts at this year's National Comprehensive Cancer Network (NCCN) Annual Conference, highlighted research in cutaneous squamous cell carcinoma (cSCC) risk evaluation using gene expression profiling.cSCC affects approximately 1.8 million Americans annually; however, identifying high-risk individuals who require more frequent monitoring and other treatment interventions has been challenging.Shlomo A. Koyfman, Director of the Precision Oncology Program and Radiation Oncologist at Cleveland Clinic, Ohio, USA, presented data from 1,412 high-risk patients with cSCC, making this study the most extensive analysis of high-risk patients stratified by gene expression profiling.Researchers integrated a 40-gene expression profile (40-GEP) test with established clinical staging methods (Brigham and Women's Hospital [BWH] staging), achieving enhanced precision in predicting the risk of metastasis compared to clinical staging alone.This integration of molecular and clinicopathological information
Author: Christos Evangelou
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4409365299