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Synthesis and antiplasmodial activity of 6 H ,13 H -pyrazino[1,2- a ;4,5- a ′]diindole analogues substituted with basic side chains

Year: 2025

Type: article

Abstract: The synthesis of pentacyclic 6 H ,13 H -pyrazino[1,2- a ;4,5- a ′]diindole analogues and their evaluation for antiplasmodial activity against 3D7 and Dd2 Plasmodium falciparum strains are reported.

Source: RSC Medicinal Chemistry

DOI: 10.1039/d4md01026d

Authors: Darius P. Zlotos, Siegrid Franke, Che J. Ngwa, Timo Reiss, Joshua Weinmann, Gabriele Pradel, Jude M. Przyborski, Ulrike Holzgrabe

Institutions: German University in Cairo, Justus-Liebig-Universität Gießen, RWTH Aachen University, University of Würzburg

Language: English

Topic: Synthesis and bioactivity of alkaloids

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Justus Liebig Universität Gießen, Deutsche Forschungsgemeinschaft, Julius-Maximilians-Universität Würzburg

OpenAlex ID: W4409365896

FWCI: 0.261

Cites: 35

Cited by: 1

Related to: 10