Work

High-fat feeding has sex-dependent effects on the structure and biomechanical properties of cerebral parenchymal arterioles and cognitive function

Year: 2025

Type: article

Abstract: Female rats fed a high-fat diet exhibited inward remodeling of the cerebral parenchymal arterioles; this structural change did not impact cerebral blood flow or cognition. In males, parenchymal arterioles from high-fat fed rats were less distensible; this biomechanical change was associated with cognitive decline and neuroinflammation but not cerebral hypoperfusion. Endothelial function was not impacted by high-fat feeding in either sex. These studies suggest that the pathophysiology of obesity-associated dementia differs between the sexes.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00295.2024

Authors: Jessica T. Yen, Theresa A. Landsell, Erinn Laimon-Thomson, Martina Yen, William F. Jackson, Anne M. Dorrance

Institution: Michigan State University

Language: English

Topic: Neurological Disease Mechanisms and Treatments

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Heart, Lung, and Blood Institute