Work

Mechanisms of DEHP in the prostate carcinogenesis: A comprehensive bioinformatics analysis

Year: 2025

Type: article

Abstract: • Network toxicology revealed 115 targets, like BCL2 and CASP3, in DEHP-linked prostate cancer toxicity. • Enrichment analysis revealed the involvement of these genes in the prominent PI3K-AKT signaling pathway in prostate cancer. • Molecular docking demonstrated binding between DEHP and prostate cancer-related target proteins.

Source: Asian Journal of Surgery

DOI: 10.1016/j.asjsur.2025.03.268

Authors: Biao Ran, Jie Chen, Dehong Cao, Liangren Liu

Institutions: Sichuan University, West China Hospital of Sichuan University

Language: English

Topic: Effects and risks of endocrine disrupting chemicals

Subfield: Health, Toxicology and Mutagenesis

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,200