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A straightforward method for measuring binding affinities of ligands to proteins of unknown concentration in biological tissues

Year: 2025

Type: article

Abstract: using native mass spectrometry which can be applied to protein-ligand complexes involving proteins of unknown concentration, from complex mixtures, including direct tissue sampling.

Source: Chemical Science

DOI: 10.1039/d5sc02460a

Authors: Bin Yan, Josephine Bunch

Institutions: National Physical Laboratory, Hammersmith Hospital, Imperial College London

Language: English

Topic: Mass Spectrometry Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funder: Cancer Research UK

Award: G5556509577

OpenAlex ID: W4409368191

FWCI: 0.506

Cites: 68

Cited by: 2

Related to: 10