Work

Chronic polydipsia and polyuria as rare renal manifestations of Sjögren's syndrome

Year: 2025

Type: article

Abstract: Sjögren's syndrome is a chronic autoimmune disorder that primarily affects the exocrine glands, with renal involvement observed in a minority of cases. We present the case of a 31-year-old woman with an 8-year history of chronic polydipsia and polyuria who was ultimately diagnosed with Sjögren's syndrome. Comprehensive evaluation revealed distal renal tubular acidosis, incomplete nephrogenic diabetes insipidus, and autoimmune serology consistent with Sjögren's syndrome. Treatment with bicarbonate, electrolyte supplementation, and immunosuppressive therapy led to significant improvement in both clinical symptoms and renal function. This case highlights the importance of considering Sjögren's syndrome in patients with chronic, unexplained polydipsia and polyuria to ensure timely diagnosis and prevent prolonged symptom persistence.

Source: EULAR Rheumatology Open

DOI: 10.1016/j.ero.2025.03.002

Authors: Vanessa Bartsch, Christiane Stark, Kathrin Standfest, Martin Blos, Stefan Knop, Axel J Hueber

Institutions: Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, Nuremberg Hospital, Paracelsus Medizinische Privatuniversität

Language: English

Topic: Salivary Gland Disorders and Functions

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,080