Work

Biodegradability and Efficacy of Porous Polycaprolactone Microsphere Dermal Filler for Fine Lines

Year: 2025

Type: article

Abstract: BACKGROUND: Among various filler products designed to improve facial wrinkles, those using biodegradable polymer microspheres have gained attention. Recently, a filler composed of porous polycaprolactone (PCL) microspheres was introduced. AIM: This study aimed to evaluate and understand the mechanism of PCL biodegradability, safety, and efficacy in reducing wrinkles. METHODS: To examine the degradation characteristics in vitro, the filler product was incubated in phosphate-buffered saline (pH 7.4) at 37°C, 45°C, and 55°C. Samples from 1 to 104 weeks were obtained to determine changes in the morphology and molecular weight of the porous PCL microspheres. In addition, the product was administered to rabbits to evaluate its in vivo degradability. Treated tissues were sampled at 6, 12, 18, 24, and 30 months to examine the biodegradability of the microspheres. Tissue safety and collagen fiber production were evaluated at the same time points. The anti-wrinkle effect was evaluated using PRIMOS to measure changes in skin surface roughness in a photoaging mouse model. RESULTS: In vitro testing revealed that the porous PCL microspheres degraded progressively over time, forming cracks on the surface and showing a decrease in molecular weight. In vivo studies demonstrated that the product degraded safely in tissues and induced collagen formation. Furthermore, skin roughness evaluation using a photoaging mouse model confirmed its anti-wrinkle effects. CONCLUSION: The filler product based on porous PCL microspheres was found to be safely biodegraded in vivo and effectively improved wrinkles.

Source: Journal of Cosmetic Dermatology

DOI: 10.1111/jocd.70156

Authors: Jin‐Su Kim, Ji‐Hyun Sung, Doo‐Yeon Kwon, Jeong‐Eun Park, Helen Cho, Hye‐Sung Yoon

Institution: Samyang Holdings (South Korea)

Language: English

Topic: Facial Rejuvenation and Surgery Techniques

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,020