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Copper (I) complex grafted functionalized-CPAM: A novel heterogeneous recyclable catalytic system for one-pot, three-component click reactions in water

Year: 2025

Type: article

Abstract: A new functionalized-MBA-crosslinked-polyacrylamide grafted with copper (I) complex (CPAM P-IA @Cu(I)) was successfully synthesized by grafting isotoic anhydride as a masked ligand onto the surface of CPAM support in two steps after which Cu(I) was immobilized by chelation. Following that, it was used for heterogeneous catalytic click reactions in water. An in-depth analysis by ICP, FTIR, DR-UV/vis, TG/DTGA, and FE-SEM revealed the changes during modifying the support and stability of the finished polymeric copper (I) catalyst during utilization. Catalytic activity is provided by active Cu(I) species stabilized by amino-amide ligands in the polymer matrix. Moreover, the CPAM anchored Cu(I) complex catalyst-mediated azide-alkyne click reactions proceeded smoothly to afford 1,2,3-triazoles with high yields within a short time. Furthermore, the reaction work-up is also straightforward, with the catalyst being recovered by easy decantation so that it can be reused for at least five repeating click reaction cycles with minimal loss of activity.

Source: Journal of Molecular Structure

DOI: 10.1016/j.molstruc.2025.142360

Authors: Ali Rahmatpour, Abolfazl Jahani

Institution: Shahid Beheshti University

Language: English

Topic: Click Chemistry and Applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $3,360

Funder: Shahid Beheshti University