Get started
Work

Conservation of strain properties of bank vole-adapted chronic wasting disease in the absence of glycosylation and membrane anchoring

Year: 2025
Type: article
Abstract: expressing transgenic mice TgVole (1×) demonstrated that the strain's distinctive rapid propagation properties were preserved. These findings suggest that neither GPI anchoring nor glycosylation are essential for maintaining CWD-vole strain properties, supporting the concept that strain characteristics are primarily encoded in the protein's misfolded structure.
DOI: 10.1016/j.nbd.2025.106894
Authors: Enric Vidal, Hasier Eraña, Jorge M. Charco, Nuria L. Lorenzo, Samanta Giler, Montserrat Ordóñez, Eva Fernández-Muñoz, Maitena San-Juan-Ansoleaga, Glenn C. Telling, Manuel A. Sánchez-Martín, Mariví Geijo, Jesús R. Requena, Joaquín Castilla
Institutions: Universitat Autònoma de Barcelona, Centre de Recerca en Sanitat Animal, Animal Health Research Center, CIC bioGUNE, Centro de Investigación Biomédica en Red, Centro de Investigación Biomédica en Red Enfermedades Infecciosas, Universidade de Santiago de Compostela, Center for Research in Molecular Medicine and Chronic Diseases, Instituto de Investigación Sanitaria de Santiago, Colorado State University, Universidad de Salamanca, Instituto de Investigación Biomédica de Salamanca, NEIKER, Basque Institute for Agricultural Research and Development, Ikerbasque
Language: English
Open Access status: gold
Estimated APC paid: $4,180
Funders: EU Joint Programme – Neurodegenerative Disease Research, European Commission, Ministerio de Ciencia e Innovación, Instituto de Salud Carlos III, European Regional Development Fund, Agencia Estatal de Investigación, National Institute of Allergy and Infectious Diseases, Interreg
Awards: G1095021113, G1175115578, G121809054, G1341303, G1384509215, G1470946416, G1622782223, G1855990336, G210041235, G2262748287, G2309174360, G2373740236, G2601397997, G2660406951, G2672435700, G279363373, G2920696644, G300979063, G3131376250, G3262627102, G34346518, G3480869486, G3518538256, G3561579476, G3681454997, G3990393904, G4042783231, G410571670, G425668148, G430777504, G4442677895, G4484702294, G451917667, G4526231891, G4820170220, G5080475149, G5105769363, G5110905163, G5195188938, G5287078650, G5295315710, G5421974903, G5539308778, G5967599077, G6358814623, G6463210894, G675437911, Biomarcadores prodrómicos en Insomnio Familiar Letal: Un estudio longitudinal en humanos y ratones, G7084143925, G7167251299, G7303235136, G7434936867, G7525641637, G7789004596, G7799207878, G8696694383, G8748079666, G8905497895, G897484643, Pathogenesis, Transmission and Detection of Zoonotic Prion Diseases, G929308097, G99296377
OpenAlex ID: W4409374627
FWCI:
Cites: 58
Cited by:
Related to: 10