Work

Retrospective study from a single center to comparison of diagnostic value of three thyroid imaging reporting and data systems in Bethesda III/IV thyroid nodules

Year: 2025

Type: article

Abstract: Objectives: To compare the diagnostic value of ACR Thyroid Imaging Reporting and Data System (TI-RADS), K-TIRADS, and C-TIRADS in Bethesda III/IV thyroid nodules. Methods: This single-center retrospective study classified 80 Bethesda stage III/IV thyroid nodules from 80 patients between January 2020 and July 2023 according to three different systems. Diagnostic performance was evaluated using receiver operating characteristic curves, with histopathological diagnosis serving as the reference standard. Results: <0.05). C-TIRADS demonstrated the highest sensitivity, accuracy, and positive predictive value, whereas ACR TI-RADS showed the highest specificity and negative predictive value. Furthermore, the AUC, sensitivity, specificity, and accuracy of ACR TI-RADS, K-TIRADS, and C-TIRADS were higher in nodules >1 cm than in those ≤ 1 cm." Conclusion: All three TI-RADS systems have diagnostic value in differentiating benign from malignant Bethesda III/IV nodules, With C-TIRADS showing the highest area under the curve(AUC), suggesting its potential utility in clinical evaluation and management of such nodules, particularly in Chinese populations.

Source: Frontiers in Oncology

DOI: 10.3389/fonc.2025.1549646

Authors: Jie Guo, Liang Du, Wenjuan Bi, Yuchen Liu, Cuiming Zhang

Institutions: Shanxi Medical University, Second Hospital of Shanxi Medical University, Southern Medical University Shenzhen Hospital, Southern Medical University

Language: English

Topic: Thyroid Cancer Diagnosis and Treatment

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801