Year: 2025
Type: article
Study design: Observational Study
Abstract: Introduction: Chronic pulmonary aspiration (CPA), a common complication of pediatric dysphagia, poses significant risks to respiratory health, potentially leading to bronchiectasis and permanent lung damage. Despite its clinical impact, the mechanisms underlying aspiration-related lung injury remain unclear. This study investigates the microbial alterations in the lungs of children with CPA and their association with immune responses. Methods: We conducted a retrospective analysis of bronchoalveolar lavage fluid (BALF) from children diagnosed with CPA and from controls without swallowing difficulties. Data were collected from patients who underwent bronchoscopy at the University Hospital Düsseldorf between 2010 and 2022. Microbial profiles-including bacterial, viral, and fungal components-and immune cell populations, were assessed to explore the relationship between microbial colonization and immune response in CPA. Results: and Enterobacterales. While the presence of mixed upper respiratory flora did not differ significantly between groups, pathogenic bacteria were more frequently detected in CPA patients. Notably, total leukocyte counts were elevated in the CPA group, yet neutrophilia was absent. Discussion: . These microbial changes may contribute to the pathogenesis of aspiration-related lung disease. Further research is needed to determine whether microbial colonization directly contributes to lung damage in and assess long-term consequences. Conclusion: Microbial dysbiosis in the lungs of children with CPA underscores the need for targeted interventions to prevent or mitigate aspiration-related lung disease. A deeper understanding of microbial colonization in CPA may pave the way for novel therapeutic strategies and improved patient outcomes.
Source: Frontiers in Pediatrics
Language: English
Subfield: Speech and Hearing
Field: Health Professions
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4409376776