Year: 2025
Type: article
Study design: Case Report
Abstract: Aggressive Angiomyxoma (AA) is an uncommon, locally invasive mesenchymal neoplasm predominantly affecting women of reproductive age. It is characterized by a notable potential for local recurrence, making it critical to distinguish AA from other mesenchymal tumors in the same anatomical regions. This tumor typically arises within the soft tissues of the pelvic region, perineum, and lower genital tract. While metastasis remains rare, the tumor's aggressive nature and propensity for local relapse highlight its clinical significance. The majority of cases occur in women during their reproductive years, underlining the age-specific risk.Presentation of caseA 23-year-old married Libyan woman presented with a gradually enlarging mass on the right labia majora, which had been present for two years. The patient’s primary concern was the increasing size of the mass, accompanied by ulceration and a clear discharge, which began in the final two months of her pregnancy and persisted for two months postpartum. There was no history of bleeding or sexual difficulties, and her menstrual cycles were regular with normal flow. Upon local examination, a well-circumscribed, pedunculated mass measuring 12 cm × 7 cm was observed (see Figures 1, 2, and 3). The mass was non-tender, with a fleshy, soft, and spongy consistency. The overlying ulcer measured 5 cm × 1 cm, with the floor showing unhealthy pale granulation tissue. Bilateral inguinal lymph nodes were not palpably enlarged. Following informed written consent, the patient underwent wide local excision of the mass along with the surrounding tissue under general anesthesia. Histopathological examination revealed the diagnosis of aggressive angiomyxoma.ConclusionAggressive angiomyxoma constitutes a key differential diagnosis when evaluating vulvovaginal masses in female patients. Given the tumor's documented propensity for local recurrence, precise diagnosis and comprehensive management strategies utilizing a multidisciplinary approach are paramount in optimizing patient care.
Authors: Sumia Dra, Fadia Oshkondale
Institution: Al Zawiya University
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4409380921