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Variability in recurrent retroperitoneal liposarcomas: A case series exploring histological subtypes

Year: 2025

Type: article

Abstract: INTRODUCTION AND IMPORTANCE: Retroperitoneal liposarcomas (RPLPS) are rare soft tissue sarcomas that often present asymptomatically, leading to delayed diagnosis and challenging management. This case series highlights the impact of histological subtypes on prognosis and recurrence. CASE PRESENTATION: Three male patients with recurrent RPLPS were compared. Two cases of well-differentiated liposarcoma (WDLPS) had favorable outcomes with tumor-free margins, despite recurrence in one. The third case, a dedifferentiated liposarcoma (DDLPS), presented with a larger, high-grade tumor requiring extensive resection and had a higher recurrence risk. CLINICAL DISCUSSION: Histological subtype, tumor size, and grade were key prognostic factors. WDLPS showed better outcomes, while DDLPS was more aggressive despite radical surgery. Recurrence remained a major concern, emphasizing the need for early detection and vigilant long-term surveillance. CONCLUSION: This case series underscores the variability in RPLPS presentation and outcomes, highlighting the need for individualized surgical strategies and close follow-up to improve long-term prognosis.

Source: International Journal of Surgery Case Reports

DOI: 10.1016/j.ijscr.2025.111284

Authors: Hesameddin Eghlimi, Hamidreza Movahedi, Parisa Pooyan

Institutions: Shahid Beheshti University, Shahid Beheshti University of Medical Sciences

Language: English

Topic: Sarcoma Diagnosis and Treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,090