Work

Histiocytic sarcoma involving multiple abdominal sites: A rare case with KRAS mutation and response to ICE chemotherapy

Year: 2025

Type: article

Abstract: Histiocytic sarcoma (HS) is a rare and aggressive malignant neoplasm from histiocytic cells. This case report describes a 52-year-old male with HS involving multiple abdominal sites, diagnosed through imaging, histopathology, and immunohistochemical analysis, which identified a KRAS mutation. The patient underwent surgical resection followed by 6 cycles of ICE chemotherapy, resulting in significant clinical improvement and reduction of tumor burden. This case highlights the clinical presentation, diagnostic challenges, and potential treatment approach for this rare malignancy.

Source: Radiology Case Reports

DOI: 10.1016/j.radcr.2025.03.045

Authors: Shahad Khalid Hussein Hussein, Olga Tcacenco

Institution: Aalborg University Hospital

Language: English

Topic: Histiocytic Disorders and Treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $600