Work

Chronic granulomatous inflammation caused by latent tuberculosis presented as a subcutaneous mass: A case report with review of literature

Year: 2025

Type: article

Abstract: Chronic granulomatous inflammation is a global disease caused by infection, auto-immune disease, toxic, or idiopathic factors. Pathological finding shows formation of distinct granulomas composed of aggregates of epithelioid macrophages, with a peripheral cuff of lymphocyte and plasma cells. Chronic granulomatous inflammation can occur in many different areas of the body, including the skin. Here, we report a case of a 64 years old woman who developed subcutaneous chronic granulomatous inflammation in the upper thigh, caused by latent tuberculosis. We also review granulomatous lesion in various countries with different incidence rate of tuberculosis and vascular feature, evaluating its effect when clinicians encounter. • Subcutaneous mass with high vascularity caused by latent tuberculosis. • Comparison of retrospective studies of granulomatous lesion by countries. • Effect of cytokines during formation of granuloma relating to angiogenesis. • How to encounter subcutaneous mass at different parts of the world.

Source: IDCases

DOI: 10.1016/j.idcr.2025.e02226

Authors: Hee Gyun Yang, Jungho Kim, Jungho Kim, Jung-Han Kim, Jung-Han Kim

Institutions: Samsung Medical Center, Sungkyunkwan University

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,370