Work

Microwave-assisted synthesis of base modified Furo[3,2-c]quinolone nucleosides and insights into their photophysical properties

Year: 2025

Type: article

Abstract: A green, catalyst free, one-pot, gram scale microwave-assisted synthesis of fluorescent furo [3,2- c ]quinolone nucleoside analogues has been successfully developed using 2-Me-THF as a greener solvent . This method, employing 3′,5′-di- O -acetyl-5-formyl-2′-deoxyuridine, alkyl isocyanides , and differently substituted 4-hydroxyquinolones, achieved product yield up to 92 %, which offers high atom economy, reduced reaction time and simple work-up procedure. The products were fully characterized by spectroscopic techniques and single crystal X-ray analysis with DFT analysis conforming the electronic structures. Fluorescence studies revealed strong emission (∼450 nm), large Stokes shifts (59–98 nm), and high quantum yields (0.053–0.595). Solvatochromism studies highlighted their environmental sensitivity, indicating potential applications in nucleic acid research and bio-imaging.

Source: Dyes and Pigments

DOI: 10.1016/j.dyepig.2025.112826

Authors: Sumit Kumar, Aditi Arora, Gautam Deo, Mrityunjay K. Tiwari, Jyotirmoy Maity, Brajendra K. Singh

Language: English

Topic: Microwave-Assisted Synthesis and Applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $3,590

Funders: Council of Scientific and Industrial Research, India, University Grants Commission, University of Delhi

Awards: G7031224598, G8182470370, G8368769304