Work

Population genetic structure analysis of Anopheles kleini in the Republic of Korea based on the mitochondrial COI gene

Year: 2025

Type: article

Abstract: BACKGROUND: Anopheles kleini is a competent vector mainly observed in the northern, malaria-risk areas of the Republic of Korea (ROK). In this study, the population genetic structure of An. kleini was analysed for the first time in the ROK using the mitochondrial cytochrome c oxidase subunit I (COI) marker. METHODS: The genetic structure of 249 An. kleini was analysed from three statistically analysable regions, each including more than five mosquitoes. RESULTS: ) values among the populations showed regional genetic differences between Gangwon-do and Gyeonggi-do. Analysis of molecular variance (AMOVA) indicated that individual mosquitoes within the population had a significant influence on the total variation. The neutrality test, using three methods (Fu's Fs, Fu, and Li's D, and Fu and Li's F), indicated that all values were negative, suggesting that An. kleini is an expanding population. Anopheles kleini in Yanggu has a significant difference in genetic distance from other regions. CONCLUSION: This study provides molecular epidemiologically information for understanding the spatial population structure of An. kleini and is helpful for malaria control in the ROK.

Source: Malaria Journal

DOI: 10.1186/s12936-025-05323-8

Authors: Haneul Jung, BoGyeong Han, Jung-Won Ju, Hee-Il Lee, Hyun-Il Shin

Institution: Korea Disease Control and Prevention Agency

Language: English

Topic: Malaria Research and Control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,890