The Role of Hematological Parameters in Critically Ill Patients: Mortality Prediction in Elderly Intensive Care Unit Patients
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background Elderly patients constitute a high-risk population in intensive care units (ICUs) due to multiple comorbidities, frailty, and limited physiological reserves. Despite advances in intensive care, mortality rates remain significantly high in this demographic. Identifying reliable predictors of mortality is crucial for early intervention and improved clinical outcomes. Hematological parameters, such as red cell distribution width (RDW), platelet-related measurements (including platelet count, mean platelet volume [MPV], and platelet distribution width [PDW]), and inflammatory markers like procalcitonin (PCT), have emerged as potential prognostic indicators. However, their predictive value in critically ill elderly patients remains controversial. Aims This study aims to determine whether hematological parameters, including RDW, platelet-related indices (platelet count, MPV, and PDW), and inflammatory markers such as PCT, can predict mortality in elderly patients admitted to ICUs. By establishing their prognostic significance, we seek to enhance early risk stratification and improve clinical decision-making. Methods A retrospective observational study was conducted on 238 patients aged 65 years and older who were admitted to the ICU. Laboratory values, demographic data, and clinical severity scores were analyzed. A receiver operating characteristic (ROC) curve analysis and logistic regression analysis were performed to assess the predictive value of hematological markers in relation to 39-day mortality. Results Among the study population, mortality occurred in 87 patients (36.6%), highlighting the high-risk nature of the geriatric intensive care cohort. RDW, PDW, MPV, and PCT levels were significantly higher in patients who did not survive (p < 0.0001). The ROC curve analysis identified PCT (area under the curve [AUC]: 0.925, p < 0.0001) and urea (AUC: 0.767, p < 0.0001) as the strongest classifiers of mortality. Logistic regression analysis confirmed PCT (odds ratio [OR]: 1.410, p < 0.0001) and PDW (OR: 1.427, p = 0.013) as independent mortality predictors. Conclusions Hematological parameters, particularly RDW, PDW, MPV, and PCT, are strong predictors of mortality in elderly patients in ICUs. These findings emphasize the role of systemic inflammation and coagulation in clinical outcomes within the intensive care setting. Integrating these parameters into clinical risk assessment models may improve early mortality prediction and allow for more targeted management strategies, ultimately improving survival in critically ill elderly patients.
Source: Cureus
DOI: 10.7759/cureus.82183
Authors: Merve Saglam Oz, Burak Toprak, Ridvan Bora, Ismail Demir
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4409397876