Year: 2025
Type: article
Study design: Observational Study
Abstract: Multiple extrahepatic organ failure is linked to the systemic disease known as hepatitis C virus infection, which contributes to its many symptoms. A kind of immune-modulating molecules called interleukins causes a variety of reactions in tissues and cells. Many of the recognized immunological "second messenger" molecules in mammals are included in these cytokines. TNF-a, IL-33, and IL-18 are linked to the onset of chronicity and liver fibrosis brought on by HCV. The ill group consisted of 75 individuals with hepatitis C, while the case control group consisted of 75 additional, apparently healthy individuals. The Center of Digestive System in Babylon Province is where the samples were taken between 16 October 2024 to 23 November 2024. Serum levels of IL-33, IL-18, and TNF-a were determined using an ELISA (enzyme-linked immunosorbent assay), and RT-PCR was performed to value the HCV load. The statistical analysis was carried out using SPSS software version 26. TNF-a, IL-33, and IL-18 levels were higher in patients than in the control group (p < 0.001). The cutoff point for the sensitivity and specificity of IL-18 in the diagnosis of HCV was > 307 ng/ml, according to the ROC curve. 95% CI = (0.754 – 0.925), AUC = 0.82, P. value = 0.0001, and sensitivity and specificity were 75.5% and 82.2%, respectively. Hepatitis C virus progression is influenced by elevated levels of IL-18, IL-33, and TNF-a, which shield hepatic tissue from viral invasion of additional cells.
Authors: Ghaith Kareem Abdul Hasan Alhijami, Seçil Akilli ŞIMŞEK
Institution: Çankırı Karatekin University
Language: English
Topic: Hepatitis C virus research
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4409397997