Work

Selective Chemoenzymatic Synthesis of Diverse Halo‐Compounds by Vanadium‐Dependent Haloperoxidase

Year: 2025

Type: article

Abstract: Compounds containing halogen atoms exhibit notable bioactivities and have found widespread applications across various fields. In this study, we report a method for synthesizing such compounds with diverse halogen atoms using vanadium‐dependent haloperoxidase from Curvularia inaequalis ( Ci VCPO). Under the optimized reaction conditions, Ci VCPO efficiently converts a broad range of halogen‐containing carboxylic acids, phenols, and anilines into the corresponding diversely halogenated products. These reactions achieved up to 99% conversion and 99% chemoselectivity under mild conditions, with a turnover number of 47750 and a turnover frequency of 27.5 s −1 for Ci VCPO. This study provides an efficient and environmentally friendly strategy for synthesizing structurally diverse halo‐compounds.

Source: ChemCatChem

DOI: 10.1002/cctc.202500584